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August 16, 2016

Arno Completes $2.8 Million Private Placement

FLEMINGTON, NJ - August 16, 2016 - Arno Therapeutics, Inc. (OTCQB:ARNI), a clinical stage biopharmaceutical company primarily focused on the development of therapeutics for cancer and other life threatening diseases, today announced that it has completed a private placement of its common stock and common stock purchase warrants that will result resulting in gross proceeds to the Company of approximately $2.8 million. The financing was led by the Company’s existing investors, including affiliates of Chairman, Arie Belldegrun, MD, OPKO Health, Inc., Commercial Street Capital LLC, Pontifax, Bonderman Family Limited Partnership, Perceptive Advisors LLC and Auriga Capital Management. The Company intends to use the proceeds from this financing to fund its ongoing clinical development of onapristone, its lead product candidate, and for general corporate purposes.

Alex Zukiwski, MD, Chief Executive Officer of Arno Therapeutics, commented, “We are very pleased to announce the closing of this financing. The proceeds will allow us to continue the clinical development of our lead product, onapristone, including enrollment in our ongoing phase 2 clinical trial in castrate resistant prostate cancer (CRPC). The Board of Directors and the management team are very grateful for the continued support shown by several of our existing investors who participated in this financing.”

Terms of Financing

The private placement was made pursuant to the terms of a securities purchase agreement entered into among the Company and the investors. Pursuant to the agreement, the Company sold units of its securities at a price of $0.35 per unit. Each unit consists of one share of common stock and a five-year warrant to purchase one-half of a share of common stock (rounded to the nearest share) at an exercise price of $0.4375 per share. In total, the securities purchase agreement covers 8.0 million shares of common stock and warrants to purchase an additional 4.0 million shares of common stock. The Company has closed on the sale of units having an aggregate purchase price of $2.3 million. The closing of the sale of the remaining securities, having an aggregate purchase price of approximately $500,000, is subject to the satisfaction of customary closing conditions set forth in the purchase agreement, including the effectiveness of a registration statement covering the resale of the shares and warrant shares. Further details of the financing have been described in a Current Report on Form 8-K to be filed with the SEC by the Company on or about August 16, 2016.

The securities sold pursuant to the securities purchase agreement were done so in reliance on an exemption from the registration requirements under the Securities Act of 1933, as amended, and may not be offered or sold in the United States absent registration under such act and applicable state securities laws or an applicable exemption from those registration requirements. The Company has agreed to file a registration statement covering the resale of the shares issued in the private placement, including the shares issuable upon exercise of the warrants. This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior the registration or qualification under the securities laws of such jurisdiction.

Clinical Development Update

The Company’s ongoing phase 2 clinical trial evaluating the combination of onapristone plus Zytiga® (abiraterone acetate) in patients with CRPC has completed the lead-in phase at 30 mg BID of onapristone plus “full dose” abiraterone acetate (5 patients) and the independent data review committee (DRC) found the combination safe. The 50 mg BID of onapristone plus “full dose” abiraterone acetate dose level is current accruing patients in the UK and US, it is anticipated that the DRC will have safety data from first group of patients (maximum 6 patients) treated at the 50 mg BID dose of onapristone in combination with abiraterone acetate for review in September 2016.

About Arno Therapeutics

Arno Therapeutics is a clinical stage biopharmaceutical company developing innovative products for the treatment of cancer and other life threatening diseases. Arno has exclusive worldwide rights to develop and market three innovative product candidates. These compounds are in clinical or preclinical development as product candidates to treat hematologic malignancies and solid tumors, as well as infectious diseases. For more information about the company, please visit

Forward-Looking Statements: This press release contains forward-looking statements that involve substantial risks and uncertainties. These statements are often, but not always, made through the use of words or phrases such as "anticipates," "expects," "plans," "believes," "intends," and similar words or phrases. These forward-looking statements include, without limitation, statements regarding the potential of onapristone as a treatment of CRPC, statements regarding the timing, progress and anticipated results of the clinical development of onapristone, as well as Arno's strategy, future operations, outlook, milestones, future financial position, future financial results, plans and objectives. Arno may not actually achieve these plans, intentions or expectations and Arno cautions investors not to place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make. Various important factors could cause actual results or events to differ materially from the forward-looking statements that we make. Such factors include, among others, risks that we will not obtain the capital necessary to fund our operations in a timely manner, if ever, or on acceptable terms, that if we are unable to obtain additional capital, we may be required to cease our ongoing clinical development activities, that the results of clinical trials will not support our claims or beliefs concerning the effectiveness of onapristone or any of our other product candidates, that we will be able to successfully develop a diagnostic to identify APR tumors, regulatory risks, and our reliance on third party researchers and other collaborators. Additional risks are described in the Company's Annual Report on Form 10-K for the year ended December 31, 2015 and in its Quarterly Report on Form 10-Q for the quarter ended June 30, 2016. Arno is providing this information as of the date of this press release and does not undertake any obligation to update any forward-looking statements as a result of new information, future events or otherwise.


Arno Therapeutics, Inc.

Alexander Zukiwski

Arno Therapeutics, Inc.
200 Route 31 North
Suite 104
Flemington, NJ 08822

(862) 703-7170 Main
(908) 237-0071 Fax